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  • Mazdutide (IBI-362, LY-3305677) peptide

Mazdutide (IBI-362, LY-3305677) peptide

Not For Human Use, Lab Use Only.

Cat.#: 319838

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Product Information

  • Product Name
    Mazdutide (IBI-362, LY-3305677) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-{Aib}-QGTFTSDYSKYLDEKKAK-{AEEA-AEEA-γGlu-Eicosanedioic acid}-EFVEWLLEGGPSSG-NH2
  • Sequence
    His-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-{AEEA-AEEA-γGlu-Eicosanedioic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2
  • Length (aa)
    34
  • Peptide Purity (HPLC)
    99.52%
  • Molecular Formula
    C207H317N45O65
  • Molecular Weight
    4563.06
  • CAS No.
    2259884-03-0
  • PubChem CID
    167312357
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Mazdutide, also known as IBI-362 or LY-3305677, is a synthetic peptide analogue of the mammalian gut hormone oxyntomodulin. It is designed as a dual agonist, with the capability to bind to and activate both the glucagon-like peptide-1 (GLP-1) receptor and the glucagon receptor. The peptide structure incorporates a fatty-acyl moiety, which extends its in vivo half-life.

    In vitro studies demonstrate that this peptide exhibits potent binding affinity for human and mouse GLP-1 and glucagon receptors. The molecular design aims to balance the activation of these two receptor pathways.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • N Engl J Med. 2025 Jun 12;392(22):2215-2225. doi: 10.1056/NEJMoa2411528. Epub 2025 May 25. PMID: 40421736.
    • Nat Commun. 2022 Jun 24;13(1):3613. doi: 10.1038/s41467-022-31328-x. PMID: 35750681; PMCID: PMC9232612.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"