Recombinant MAGI3 protein (His tag)

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Recombinant Human MAGI-3 Fragment (294-497): A high-purity protein fragment encompassing the WW 2 and PDZ 2 domains of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (MAGI-3). This product is an essential tool for investigating domain-specific interactions in cellular scaffolding, junctional signaling, and regulatory processes such as AKT1 modulation.

MAGI-3 acts as a critical scaffolding protein localized at cell-cell junctions, including tight junctions in epithelial cells, and also exhibits nuclear presence. It regulates diverse cellular and signaling pathways by cooperating with PTEN to modulate AKT1 kinase activity, linking receptor tyrosine phosphatases with substrates at the plasma membrane, facilitating TGFA trafficking, and influencing ERK, RhoA, and JNK signaling cascades through interactions with partners like LPAR2, FZD4, and VANGL2. This positions MAGI-3 as a key player in maintaining cellular structure and signal transduction integrity.