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  • Magainin II

Magainin II

Cat.#: 318722

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 204.4 USD

Availability: 3 weeks
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Product Information

  • Product Name
    Magainin II
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    GIGKFLHSAKKFGKAFVGEIMNS
  • Three letter code
    H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser-OH
  • Length (aa)
    23
  • Peptide Purity (HPLC)
    95.1
  • Molecular Formula
    C114H180N30O29S
  • Molecular Weight
    2466.91
  • Source
    Synthetic
  • Additional Information
    Magainin 2 assumes an amphiphilic helix when bound to acidic phospholipids, forming a pore composed of a dynamic, peptide-lipid supramolecular complex. Magainin II, an antibiotic peptide. Magainins are positively charged and amphiphatic. Thought to preferentially bind to anionic phospholipids abundant in bacterial membranes with the formation of dynamic peptide-lipid supramolecular pore and cell permeabilization. Binding to artificial neutral membranes has also been demonstrated.
  • Storage Guidelines
    Ideally Magainin II should be stored in a freezer at or below -9C. Magainin II should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Hocquellet A, Odaert B, Cabanne C, et al. Structure-activity relationship of human liver-expressed antimicrobial peptide 2. Peptides. 2010;31(1):58-66
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-GIGKFLHSAKKFGKAFVGEIMNS-OH
  • Chemical Formula:C114H180N30O29S
  • Sequence length:23
  • Extinction coefficient:0 M-1cm-1
  • GRAVY:0.08
  • Mw average:2466.89
  • Theoretical pI:10.55
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

Red: Hydrophobic uncharged residues, like F I L M V W A and P

Blue: Basic residues, like R K H and N-terminal -NH2

Green: Acidic residues, like D E and C-terminal -COOH

Black: Polar uncharged residues, like G S T C N Q and Y

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"