MACTIDE peptide

MACTIDE peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-GC*TKSIPPIC*SPGAK-OH (disulfide bond: Cys2-Cys10)

H-Gly-Cys-Thr-Lys-Ser-Ile-Pro-Pro-Ile-Cys-Ser-Pro-Gly-Ala-Lys-OH (disulfide bond: Cys2-Cys10)

15

95.38%

C₆₂H₁₀₅N₁₇O₁₉S₂

1456.72

Synthetic

Powder

MACTIDE is an engineered CD206-targeting peptide designed to enhance the affinity and proteolytic stability of its predecessor, mUNO. By incorporating a trypsin inhibitor loop from Sunflower Trypsin Inhibitor-1 (SFTI-1), MACTIDE adopts a constrained structure, improving its binding to CD206 (15-fold lower KD than mUNO) and extending its half-life in tumor environments (5-fold increase). It effectively homes to CD206+ tumor-associated macrophages (TAMs) in triple-negative breast cancer (TNBC) models.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Lepland A, Peranzoni E, Haljasorg U, Asciutto EK, Crespí-Amer M, Modesti L, Kilk K, Lombardia M, Acosta G, Royo M, Peterson P, Marigo I, Teesalu T, Scodeller P. Peptide-Drug Conjugate for Therapeutic Reprogramming of Tumor-Associated Macrophages in Breast Cancer. Adv Sci (Weinh). 2025 Mar;12(10):e2410288. doi: 10.1002/advs.202410288. Epub 2025 Jan 22. PMID: 39840532; PMCID: PMC11904948.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.