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Recombinant M21D2 protein (His tag)

Cat.#: 540698

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Product Information

  • Product Name
    Recombinant M21D2 protein (His tag)
  • Documents
  • Description

    Recombinant Human Nucleotidyltransferase MB21D2 (EC 2.7.7.-), encompassing amino acids 1-431, is a high-purity protein fragment designed for structural and biochemical studies. This product captures a stable, soluble unit of MB21D2, enabling researchers to investigate its role in cyclic dinucleotide synthesis and signaling pathways.

    MB21D2, encoded by the gene MB21D2 in Homo sapiens, is a probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messengers in response to unknown stimuli. These cyclic dinucleotides are critical signaling molecules involved in immune responses and cellular communication, as supported by research (PubMed:34261127). The recombinant fragment (1-431) was selected computationally to ensure stability and solubility, facilitating experimental analysis of its enzymatic activity and structural properties.

  • Protein name
    Nucleotidyltransferase MB21D2
  • Uniprot ID
    Q8IYB1
  • Gene Name
    MB21D2; C3orf59
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 1-431 aa (Q8IYB1) were fused with C-terminal 6His tag.
  • Sequence 
    MKMAAPTANK AASLGCNNKP AFPELDFRSG ARVEELNKLI QEFTKHDQRE YDDQRALEIH TAKDFIFSML GMVQKLDQKL
PVANEYLLLS GGVREGVVDL DLDELNVYAR GTDYDMDFTL LVPALKLHDR NQPVTLDMRH SALCHSWLSL RLFDEGTISK
WKDCCTIVDH INGATNYFFS PTKVADWFYD SISIVLSEIQ KKPQRGMPKV EKVEKNGTII SIILGVGSSR MLYDIVPVVS
FKGWPAVAQS WLMENHFWDG KITEEEVISG FYLVPACSYK GKKDNEWRLS FARSEVQLKK CISSSLMQAY QACKAIIIKL
LSRPKAISPY HLRSMMLWAC DRLPANYLAQ EDYAAHFLLG LIDDLQHCLV NKMCPNYFIP QCNMLEHLSE ETVMLHARKL
SSVRSDPAEH LRTAIEHVKA ANRLTLELQR RLEHHHHHH
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 50.25 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 52 kDa band.
  • Purity
    >90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.
  • Validations

    Recombinant M21D2 protein (His tag) SDS-PAGE

    Recombinant M21D2 protein (His tag) SDS-PAGE

    M: Marker; Lane 1: M21D2; Lane 2: BSA

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"