M12 peptide

M12 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-RRQPPRSISSHP-OH

H-Arg-Arg-Gln-Pro-Pro-Arg-Ser-Ile-Ser-Ser-His-Pro-OH

12

95.9%

C₅₉H₁₀₀N₂₄O₁₇

1417.57

Synthetic

Powder

M12 is a novel 12-mer peptide showing preferential binding to skeletal muscle compared to the liver. M12 peptide preferentially binds to skeletal muscle after systemic administration in adult mdx mice. When M12 was conjugated to PMO(phosphorodiamidate morpholino), the M12–PMO conjugate could effectively induce exon skipping and dystrophin restoration in body-wide skeletal muscles with the exception of heart after systemic administration in mdx mice. M12-PMO oligomer can be an alternative option to current AOs(Antisense oligonucleotide).

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Gao X, Zhao J, Han G, Zhang Y, Dong X, Cao L, Wang Q, Moulton HM, Yin H. Effective dystrophin restoration by a novel muscle-homing peptide-morpholino conjugate in dystrophin-deficient mdx mice. Mol Ther. 2014 Jul;22(7):1333-1341. doi: 10.1038/mt.2014.63. Epub 2014 Apr 15. Erratum in: Mol Ther. 2020 Oct 7;28(10):2299-2301. PMID: 24732757; PMCID: PMC4088999.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.