Recombinant LYN protein (His tag)

• DataSheet
• COA (Batch NP456484)
• Material Safety Data Sheets (MSDS)

Recombinant Human Lyn Kinase Fragment (66-512) is a high-purity protein product encompassing the complete SH2 and Protein Kinase domains of Tyrosine-protein kinase Lyn. This fragment serves as an essential research tool for investigating immune signaling pathways, kinase activity, and domain-specific interactions in B-cell regulation, hematopoiesis, and inflammatory responses.

Tyrosine-protein kinase Lyn (encoded by the LYN gene) is a non-receptor tyrosine kinase that plays a pivotal role in regulating innate and adaptive immune responses, hematopoiesis, and cellular signaling pathways. It functions as both a negative regulator and activator depending on cellular context, primarily transmitting signals from immune receptors including B-cell receptors, FC receptors, and Toll-like receptors. Lyn is crucial for B-cell differentiation, proliferation, survival, and immune self-tolerance, while also mediating responses to growth factors, cytokines, and integrin signaling in hematopoietic cells. The protein

MNHKVDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK LNTLETEEWF FKDITRKDAE
RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR
RLEKACISPK PQKPWDKDAW EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD
KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER KNYIHRDLRA ANVLVSESLM
CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY
RMPRVENCPD ELYDIMKMCW KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QPLEHHHHHH