LTX-315 peptide

LTX-315 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

KKWWKKW(Dip)K-NH2

Lys-Lys-Trp-Trp-Lys-Lys-Trp-Dip-Lys-NH2

9

97.76%

C₇₈H₁₀₆N₁₈O₉

1439.79

1345407-05-7

46200994

Synthetic

Powder

LTX-315 (Synonyms: K-K-W-W-K-K-W-Dip-K-NH2, Ruxotemitide, Oncopore) is a synthetic anticancer peptide derived from human lactoferrin, has the potential to adopt an amphipathic helical coil structure and was designed for intralesional treatment of tumors. LTX-315 was highly active against both murine and human melanoma cell lines in vitro, while displaying low EC50 cytotoxic activity against human red blood cells. Furthermore, when syngeneic B16 melanomas were treated intralesionally, a majority of the animals (~80%) treated with LTX-315 experienced a complete and long-lasting tumor regression. LTX-315 (Ruxotemitide, Oncopore) kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Camilio KA, Rekdal O, Sveinbju00f6rnsson B. LTX-315 (Oncoporeu2122): A short synthetic anticancer peptide and novel immunotherapeutic agent. Oncoimmunology. 2014

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.