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Product Name
Recombinant LSM1 protein (His tag)
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Description
Recombinant Human LSm1 Fragment (1-133) is a high-purity protein product encompassing the complete Sm domain of the U6 snRNA-associated Sm-like protein LSm1. This fragment serves as an essential tool for investigating the protein's role in histone mRNA degradation and cytoplasmic mRNA decay pathways.
The full-length LSm1 protein in Homo sapiens plays a critical role in the degradation of histone mRNAs, which are unique among eukaryotic mRNAs for lacking polyadenylation. It functions in the cytoplasm, particularly within P-bodies, and is believed to participate in broader mRNA degradation processes as part of an LSm subunit-containing complex. The protein's involvement in these specific RNA regulatory mechanisms makes it significant for studies of post-transcriptional gene regulation and RNA metabolism.
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Protein name
U6 snRNA-associated Sm-like protein LSm1
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Uniprot ID
O15116
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Gene Name
LSM1; CASM
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-133 aa (O15116) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 16.83 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 19 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"