LRELHLNNN peptide

LRELHLNNN peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-LRELHLNNN-OH

H-Leu-Arg-Glu-Leu-His-Leu-Asn-Asn-Asn-OH

9

95.38%

C₄₇H₇₉N₁₇O₁₅

1122.23

Synthetic

Powder

Peptide LRELHLNNN is a small chain of amino acids that has been identified as having the ability to selectively bind to collagen type I, which is an important protein in fibrosis. Fibrosis refers to the pathological formation of excess connective tissue and can occur in many diseases including liver and pancreas disease. The affinity (or strength) of binding between peptide LRELHLNNN and collagen type I was measured at 170 nM. Researchers have modified this peptide by attaching it to a molecule called DOTA/NOTA via a PEG2-linker. This modification allows for radiolabeling with Gallium-68 or aluminium fluoride-18, making it useful as a PET tracer for detecting fibrotic lesions non-invasively.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Maria, Rosestedt., Irina, Velikyan., Ulrika, Rosenström., Sergio, Estrada., Ola, Åberg., Jan, Weis., Christer, Westerlund., Sofie, Ingvast., Olle, Korsgren., Patrik, Nordeman., Olof, Eriksson. (2021). Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1.. Nuclear Medicine and Biology, 93:54-62. doi: 10.1016/J.NUCMEDBIO.2020.11.006

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.