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Product Name
Recombinant LR2BP protein (His tag)
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Description
Recombinant Human LRP2-binding protein (MegBP) fragment (amino acids 1-347) is a high-quality, soluble protein designed for structural and functional studies. This stable fragment enables researchers to investigate the adapter role of MegBP in regulating LRP2 (Megalin) activity, supporting biochemical and structural analyses.
The full-length LRP2-binding protein (MegBP) functions as an adapter that modulates the activity of LRP2 (Megalin), a critical receptor involved in endocytic pathways and cellular signaling. It is localized primarily in the cytoplasm, displaying a vesicular staining pattern near the plasma membrane and throughout the cytosol, suggesting involvement in intracellular trafficking and receptor regulation. This recombinant fragment represents a stable, soluble unit ideal for exploring MegBP's mechanistic role in LRP2-mediated processes.
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Protein name
LRP2-binding protein
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Uniprot ID
Q9P2M1
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Gene Name
LRP2BP; KIAA1325
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-347 aa (Q9P2M1) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 41.44 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 43 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"