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  • LL 37 (18-37) (human) peptide

LL 37 (18-37) (human) peptide

Not For Human Use, Lab Use Only.

Cat.#: 319117

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Product Information

  • Product Name
    LL 37 (18-37) (human) peptide
  • Documents
  • Sequence Shortening
    H-KRIVQRIKDFLRNLVPRTES-OH
  • Sequence
    H-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    95.19%
  • Molecular Formula
    C109H190N36O29
  • Molecular Weight
    2468.89
  • Source
    Synthetic
  • Form
    Powder
  • Description
    LL 37 (18-37) (human) is the C-terminal 20 amino acids of LL 37 [AM-001], the host defense peptide that plays a crucial role in innate and adaptive immunity in humans. LL 37 (18-37) is a postsecretory product of LL 37 and a natural component of human sweat. LL 37 (18-37) has enhanced antibacterial and antifungal activity relative to full length LL 37.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Murakami et al (2004) Postsecretory Processing Generates Multiple Cathelicidins for Enhanced Topical Antimicrobial Defense. J. Immunol. 172(5) 3070 PMID: 14978112
    • Wu et al (2010) Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. Int. J. Cancer. 127(8) 1741 PMID: 20521250
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"