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  • Leptin (116-130) amide (mouse) peptide

Leptin (116-130) amide (mouse) peptide

Not For Human Use, Lab Use Only.

Cat.#: 312140

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Product Information

  • Product Name
    Leptin (116-130) amide (mouse) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    SCSLPQTSGLQKPES-NH2
  • Sequence
    H-Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2
  • Length (aa)
    15
  • Peptide Purity (HPLC)
    95.77%
  • Molecular Formula
    C64H109N19O24S
  • Molecular Weight
    1560.71
  • Source
    Synthetic
  • Form
    Powder
  • Description
    This leptin fragment had the ability to mimic the effects of recombinant leptin on body weight and food intake in female ob/ob mice that lack endogenously circulating active leptin. Daily intraperitoneal administration of 1 mg of this peptide for 28 days caused a body weight loss of 3.4% (control +14.7%). Food intake was reduced by 15%.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • P.Grasso et al., Endocrinology, 138, 1413 (1997)
    • Malekizadeh Y, Holiday A, Redfearn D, Ainge JA, Doherty G, Harvey J. A Leptin Fragment Mirrors the Cognitive Enhancing and Neuroprotective Actions of Leptin. Cereb Cortex. 2017 Oct 1;27(10):4769-4782. doi: 10.1093/cercor/bhw272. PMID: 27600840; PMCID: PMC6433184.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"