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  • little LEN peptide

little LEN peptide

Not For Human Use, Lab Use Only.

Cat.#: 308696

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Product Information

  • Product Name
    little LEN peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    LETPAPQVPA
  • Sequence
    H-Leu-Glu-Thr-Pro-Ala-Pro-Gln-Val-Pro-Ala-OH
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    98.54%
  • Molecular Formula
    C46H75N11O15
  • Molecular Weight
    1022.15
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The little LEN peptide is a bioactive peptide derived from the proprotein convertase subtilisin/kexin type 1 inhibitor (proSAAS). Its sequence is LETPAPQVPA, corresponding to residues 245-254 of the proSAAS precursor protein. This peptide is generated through specific proteolytic cleavage at dibasic amino acid sites, a characteristic processing mechanism for neuroendocrine peptides. In cerebrospinal fluid (CSF) peptidomics studies, the intact form of little LEN has been identified alongside other proSAAS-derived peptides.

    Research indicates that peptides originating from the proSAAS protein, including little LEN, are present in the CSF peptidome. These peptides are of interest due to their potential physiological activity and their altered abundance in neurodegenerative conditions. The identification of such specific peptide forms contributes to the understanding of the complex peptidomic landscape within the central nervous system.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Fricker LD, Mckinzie AA, Sun J, et al. Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. J Neurosci. 2000;20(2):639-48.
    • Muqaku B, Oeckl P. Peptidomic Approaches and Observations in Neurodegenerative Diseases. Int J Mol Sci. 2022 Jun 30;23(13):7332. doi: 10.3390/ijms23137332. PMID: 35806335; PMCID: PMC9266836.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"