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  • Larazotide acetate peptide

Larazotide acetate peptide

Not For Human Use, Lab Use Only.

Cat.#: 319762

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Product Information

  • Product Name
    Larazotide acetate peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-GGVLVQPG-OH
  • Sequence
    H-Gly-Gly-Val-Leu-Val-Gln-Pro-Gly-OH
  • Length (aa)
    8
  • Peptide Purity (HPLC)
    97.46%
  • Molecular Formula
    C32H55N9O10
  • Molecular Weight
    725.85
  • CAS No.
    258818-34-7
  • PubChem CID
    9810532
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Biological Activity: Larazotide is a polypeptide and an orally active zonulin antagonist. It exhibits antiviral activity against varicella-zoster virus (VZV), with EC50 values of 44.14 μM and 59.06 μM for the OKA and 07-1 strains, respectively. Larazotide can be used in studies related to celiac disease and infections
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A. Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. Int J Mol Sci. 2021 Aug 30;22(17):9427. doi: 10.3390/ijms22179427. PMID: 34502335; PMCID: PMC8431481.
    • Slifer ZM, Hernandez L, Pridgen TA, Carlson AR, Messenger KM, Madan J, Krishnan BR, Laumas S, Blikslager AT. Larazotide acetate induces recovery of ischemia-injured porcine jejunum via repair of tight junctions. PLoS One. 2021 Apr 22;16(4):e0250165. doi: 10.1371/journal.pone.0250165. PMID: 33886649; PMCID: PMC8061941.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"