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Product Name
Recombinant KYNU protein (His tag)
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Description
Recombinant Human Kynureninase (KYNU) Fragment (1-465) is a high-quality protein product designed for structural and biochemical studies. This fragment encompasses the full-length protein (EC 3.7.1.3), which functions as L-kynurenine hydrolase, and has been computationally optimized for stability and solubility to support reliable research applications.
Kynureninase, encoded by the KYNU gene in Homo sapiens, is a cytoplasmic enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic acid and 3-hydroxyanthranilic acid, respectively, with a preference for the L-3-hydroxy form. It also exhibits cysteine-conjugate-beta-lyase activity. Located in the cytosol, this enzyme plays a critical role in the kynurenine pathway, which is involved in tryptophan metabolism and has implications in immune regulation and neurological processes. The provided fragment (residues 1-465) represents a stable, soluble unit ideal for investigating protein structure and function.
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Protein name
Kynureninase
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Uniprot ID
Q16719
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Gene Name
KYNU
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-465 aa (Q16719) were fused with 6His tag.
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Sequence
1-465
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 54.01 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 55 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"