Recombinant KVD40 protein (His tag)

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Recombinant Immunoglobulin kappa variable 2D-40 (Ig kappa chain V-II region Cum) fragment (residues 20-121) offers a stable and soluble unit of this human variable domain, ideal for investigating antigen recognition mechanisms and antibody engineering applications.

Immunoglobulin kappa variable 2D-40 is the variable region of immunoglobulin light chains, playing a critical role in antigen recognition during humoral immunity. As part of antibodies produced by B lymphocytes, it contributes to the antigen-binding site formed with its associated heavy chain variable domain. These membrane-bound immunoglobulins serve as antigen receptors that trigger B cell activation and differentiation, while secreted forms mediate antigen elimination. The variable domains undergo V-(D)-J rearrangement and somatic hypermutations, enabling remarkable antigen affinity and maturation. This protein is naturally found both secreted and membrane-bound in human cells, highlighting its dual role in immune recognition and response.