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  • KLKL5KLK peptide

KLKL5KLK peptide

Not For Human Use, Lab Use Only.

Cat.#: 319431

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Product Information

  • Product Name
    KLKL5KLK peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-KLKLLLLLKLK-NH2
  • Sequence
    H-Lys-Leu-Lys-Leu-Leu-Leu-Leu-Leu-Lys-Leu-Lys-NH2
  • Length (aa)
    11
  • Peptide Purity (HPLC)
    99.55%
  • Molecular Formula
    C66H128N16O11
  • Molecular Weight
    1321.8
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The artificial cationic antimicrobial peptide KLKL5KLK (H-KLKLLLLLKLK-NH2) is a synthetic undecapeptide derived from sapecin B, modified to enhance activity. It exhibits structural features typical of cationic antimicrobial peptides, characterized by a palindromic sequence with alternating hydrophobic and cationic residues. This design promotes interactions with biological membranes and cell surfaces.

    KLKL5KLK demonstrates the ability to enhance antigen association with antigen-presenting cells in vitro and forms a transient antigen depot at the injection site in vivo. The peptide retains its immuno-enhancing properties despite C-terminal amidation or synthesis with D-amino acids, indicating that its activity depends primarily on amino acid side chain sequence rather than backbone stereospecificity. It predominantly induces a TH2-type immune polarization profile when co-administered with proteinaceous or peptide-based antigens, as evidenced by elevated IL-4 and IL-5 production and sustained antibody responses.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Fritz JH, Brunner S, Birnstiel ML, Buschle M, Gabain Av, Mattner F, Zauner W. The artificial antimicrobial peptide KLKLLLLLKLK induces predominantly a TH2-type immune response to co-injected antigens. Vaccine. 2004 Sep 3;22(25-26):3274-84. doi: 10.1016/j.vaccine.2004.03.007. PMID: 15308350.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"