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Product Name
Recombinant KIF5C protein (His tag)
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Description
Recombinant Kinesin heavy chain isoform 5C (KIF5C) fragment (amino acids 1-380), encompassing the complete kinesin motor domain. This high-purity human protein is ideal for investigating microtubule-associated force production, ATPase activity, and motor function in neuronal transport and organelle dynamics.
Kinesin heavy chain isoform 5C (KIF5C) is a microtubule-associated force-producing protein involved in ATP-dependent organelle transport and synaptic transmission. It mediates dendritic mRNA trafficking and is required for anterograde axonal transport of proteins like MAPK8IP3/JIP3, crucial for axon elongation. The protein localizes to the cytoplasm, cytoskeleton, and dendrites, with abundance in distal dendritic regions, highlighting its role in neuronal polarity and intracellular logistics.
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Protein name
Kinesin heavy chain isoform 5C
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Uniprot ID
O60282
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Gene Name
KIF5C; KIAA0531; NKHC2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-380 aa (O60282) were fused with C-terminal 6His tag.
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Sequence
MADPAECSIK VMCRFRPLNE AEILRGDKFI PKFKGDETVV IGQGKPYVFD RVLPPNTTQE QVYNACAKQI VKDVLEGYNG TIFAYGQTSS GKTHTMEGKL HDPQLMGIIP RIAHDIFDHI YSMDENLEFH IKVSYFEIYL DKIRDLLDVS KTNLAVHEDK NRVPYVKGCT ERFVSSPEEV MDVIDEGKAN RHVAVTNMNE HSSRSHSIFL INIKQENVET EKKLSGKLYL VDLAGSEKVS KTGAEGAVLD EAKNINKSLS ALGNVISALA EGTKTHVPYR DSKMTRILQD SLGGNCRTTI VICCSPSVFN EAETKSTLMF GQRAKTIKNT VSVNLELTAE EWKKKYEKEK EKNKTLKNVI QHLEMELNRW RNGEAVPEDE LEHHHHHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 43.91 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 48 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant KIF5C protein (His tag) SDS-PAGE
M: Marker; Lane 1: KIF5C; Lane 2: BSA
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