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  • KFP-1 peptide

KFP-1 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319869

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* Buy 1 get 1 free (?) What is TFA?

Special Price 156.20 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    KFP-1 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    TEVPAINTIASAEPTVH
  • Sequence
    Thr-Glu-Val-Pro-Ala-Ile-Asn-Thr-Ile-Ala-Ser-Ala-Glu-Pro-Thr-Val-His
  • Length (aa)
    17
  • Peptide Purity (HPLC)
    97%
  • Molecular Formula
    C76H124N20O27
  • Molecular Weight
    1749.941
  • Source
    Synthetic
  • Form
    Powder
  • Description

    KFP-1 is a 17-residue peptide (TEVPAINTIASAEPTVH) isolated from kefir, a fermented dairy beverage. This peptide is characterized as a calcium-binding peptide that facilitates intestinal calcium absorption through TRPV6 channels. In vitro studies demonstrate that KFP-1 promotes osteoblast differentiation and mineralization. It upregulates key osteogenic markers and transcription factors, including ALP, Col1a1, OCN, RUNX2, OSX, BMP-2, and β-catenin.

    Concurrently, KFP-1 exhibits inhibitory effects on osteoclast differentiation and bone resorption. It downregulates osteoclastic markers such as cathepsin K, TRAP, and NFATc1, and suppresses RANKL-induced signaling pathways, including p38 MAPK, JNK, ERK, and NF-κB. Biodistribution analyses indicate that KFP-1 can reach bone tissue following oral administration. The collective data indicate that KFP-1 possesses a dual function in modulating bone remodeling by enhancing osteogenic activity and inhibiting osteoclastic activity.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Tung MC, Chang GR, Tu MY, Fan HC, Yen CC, Cidem A, Chen IC, Chen CM. Dual Osteoprotective Actions of the Kefir Peptide KFP-1: Enhancement of Bone Formation and Suppression of Bone Resorption in Cells and Murine Models. Calcif Tissue Int. 2026 Feb 17;117(1):32. doi: 10.1007/s00223-026-01487-w. PMID: 41703166; PMCID: PMC12913355.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"