KEMPFPKYPVEP peptide

KEMPFPKYPVEP peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-KEMPFPKYPVEP-OH

H-Lys-Glu-Met-Pro-Phe-Pro-Lys-Tyr-Pro-Val-Glu-Pro-OH

12

95.11%

C₇₀H₁₀₄N₁₄O₁₈S

1461.72

Synthetic

Powder

KEMPFPKYPVEP is a peptide identified from a screen of digested casein protein for the ability to improve spatial memory in amnesia mouse models. KEMPFPKYPVEP peptide was found to prevent scopolamine induced deficit in short term spatial memory, and also enhance long term object recognition memory in intact mice, with increased levels of dopamine and norepinephrine, but not serotonin being found in the frontal cortex. Previous epidemiological investigations have indicated that consuming dairy products can prevent cognitive decline, however only cheese fermented with fungi contains the KEMPFPKYPVEP peptide, which is found at the highest level in Camembert at 14.58-39.02 pmol per gram.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Ano et al (2019) Identification of a Novel Peptide from β-Casein That Enhances Spatial and Object Recognition Memory in Mice. J Agric Food Chem. 67(29) 8160 PMID: 31241932

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.