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Product Name
Recombinant KCTD3 protein (His tag)
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Description
Recombinant KCTD3 (BTB/POZ domain-containing protein KCTD3) fragment (amino acids 1-138) from Homo sapiens, encompassing the full BTB domain. This high-purity protein is an essential tool for investigating the role of KCTD3 as an accessory subunit in regulating HCN3 channel expression and function.
The full-length BTB/POZ domain-containing protein KCTD3, also known as Renal carcinoma antigen NY-REN-45, functions as an accessory subunit of the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3). It upregulates HCN3's cell-surface expression and current density without altering its voltage dependence or kinetics, highlighting its critical role in modulating channel activity. KCTD3 is localized to the cell membrane, where it participates in ion channel regulation. This recombinant fragment (1-138) contains the complete BTB domain (residues 18-87), enabling focused studies on domain-specific interactions and functional mechanisms.
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Protein name
BTB/POZ domain-containing protein KCTD3
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Uniprot ID
Q9Y597
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Gene Name
KCTD3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-138 aa (Q9Y597) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 16.68 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 17 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"