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Product Name
Recombinant KCD17 protein (His tag)
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Description
Introducing the recombinant BTB/POZ domain-containing protein KCTD17 fragment (amino acids 1-214), a high-purity tool designed for studying the BTB domain's role in ubiquitin ligase complex formation and ciliogenesis regulation. This human-derived fragment enables targeted investigation of domain-specific functions in protein degradation pathways and cellular processes.
The full-length KCTD17 protein (UniProt ID: Q8N5Z5) functions as a substrate-adapter for CUL3-RING ubiquitin ligase complexes, mediating the ubiquitination and proteasomal degradation of TCHP, a key regulator of ciliogenesis. Through this mechanism, KCTD17 positively regulates ciliogenesis and plays a crucial role in the initial steps of axoneme extension. Additionally, research suggests potential involvement in endoplasmic reticulum calcium ion homeostasis. The protein is primarily localized to the cytoplasm, where it executes its regulatory functions in protein degradation and cellular signaling pathways.
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Protein name
BTB/POZ domain-containing protein KCTD17
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Uniprot ID
Q8N5Z5
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Gene Name
KCTD17
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-214 aa (Q8N5Z5) were fused with N-terminal 6His tag.
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Sequence
MSKIKHHHHH HGGSMRMEAG EAAPPAGAGG RAAGGWGKWV RLNVGGTVFL TTRQTLCREQ KSFLSRLCQG EELQSDRDET GAYLIDRDPT YFGPILNFLR HGKLVLDKDM AEEGVLEEAE FYNIGPLIRI IKDRMEEKDY TVTQVPPKHV YRVLQCQEEE LTQMVSTMSD GWRFEQLVNI GSSYNYGSED QAEFLCVVSK ELHSTPNGLS SESSRKTKST EEQLEEQQ
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 25.76 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 28 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"