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Product Name
Recombinant JUNB protein (His tag)
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Description
Introducing the recombinant human Transcription factor JunB fragment (residues 261-347), a high-purity protein designed to encompass the complete bZIP functional domain. This fragment serves as an essential tool for researchers studying AP-1 transcription complex formation, DNA binding mechanisms, and gene regulation pathways in cellular processes.
Transcription factor JunB (UniProt ID: P17275) is a key regulatory protein in Homo sapiens that functions as a component of the AP-1 transcription complex. It binds to the DNA sequence 5'-TGA[GC]TCA-3' and heterodimerizes with FOS family proteins to enhance DNA binding affinity and transcriptional activity, primarily regulating gene expression following growth factor responses. JunB is localized exclusively in the nucleus, where it orchestrates fundamental cellular processes through its role in the primary growth factor response pathway.
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Protein name
Transcription factor JunB
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Uniprot ID
P17275
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Gene Name
JUNB
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 261-347 aa (P17275) were fused with N-terminal 6His tag.
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Sequence
MSKIKHHHHH HGGSINMEDQ ERIKVERKRL RNRLAATKCR KRKLERIARL EDKVKTLKAE NAGLSSTAGL LREQVAQLKQ KVMTHVSNGC QLLLGVKGHA F
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 11.52 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant JUNB protein (His tag) SDS-PAGE
M: Marker; Lane 1: JUNB; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"