Integerrimide B peptide

Integerrimide B peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

cyclo(WALLVSP)

cyclo(-Trp-Ala-Leu-Leu-Val-Ser-Pro-)

7

95.69%

C₃₉H₆₀N₈O₉

784.94

Synthetic

Powder

Integerrimide B is a cyclic heptapeptide isolated from the latex of peregrina / spicy jatropha (Jatropha integerrima).
Integerrimide B significantly inhibited neurite outgrowth in neuronal cell culture at 50 uM.
It partially inhibited proliferation of human IPC-298 melanoma cells and migration of human Capan II pancreatic carcinoma cells.
Integerrimide B was inactive in HSV-1, antifungal, and antimalarial assays.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Mongkolvisut W, Sutthivaiyakit S, Leutbecher H, et al. Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima. J Nat Prod. 2006;69(10):1435-41.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.