Recombinant IL8 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

This product is a high-quality recombinant protein fragment of Human Interleukin-8 (IL-8), encompassing amino acids 21-99. This 79-amino acid fragment is designed to be a stable and soluble unit, ideal for structural studies, biochemical assays, and investigating the chemotactic and neutrophil-activating functions of this key inflammatory cytokine.

Interleukin-8 (IL-8), also known as CXCL8, is a potent chemotactic cytokine secreted by various cell types in response to inflammatory stimuli. Its primary function is to mediate the inflammatory response by attracting and activating neutrophils, basophils, and T-cells to the site of infection or injury, thereby aiding in pathogen clearance and host defense. IL-8 exerts its effects by binding to the G-protein-coupled receptors CXCR1 and CXCR2 on target cells, such as neutrophils and monocytes. This binding triggers intracellular signaling cascades, including the PI3K and MAPK pathways, leading to cell migration and activation. As a secreted protein, IL-8 plays a central role in numerous inflammatory and immune processes.