Recombinant IGF1R protein (His tag)

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This recombinant protein product features a specific fragment (amino acids 775-935) of the human Insulin-like Growth Factor 1 Receptor (IGF1R), encompassing the Fibronectin type-III 4 domain. It serves as an essential tool for researchers studying receptor structure, ligand interactions, and domain-specific functions in growth signaling pathways.

The full-length Insulin-like Growth Factor 1 Receptor (IGF1R) is a receptor tyrosine kinase that primarily mediates the biological effects of Insulin-like Growth Factor 1 (IGF1), playing crucial roles in cell growth, survival, and metabolism. Upon ligand binding, IGF1R undergoes autophosphorylation and activates multiple downstream signaling pathways including PI3K-AKT and Ras-MAPK, which regulate cellular proliferation, protein synthesis, and apoptosis inhibition. The receptor is particularly significant in cancer biology, where it contributes to tumor transformation and malignant cell survival. IGF1R is located at the cell membrane as a single-pass type I membrane protein and can form hybrid receptors with insulin receptor isoforms, displaying varying affinities for IGF1, IGF2, and insulin. The provided fragment containing the Fibronectin type-III 4 domain represents a structurally and functionally important region of this critical signaling receptor.