IDR-1018 peptide

IDR-1018 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-VRLIVAVRIWRR-NH2

H-Val-Arg-Leu-Ile-Val-Ala-Val-Arg-Ile-Trp-Arg-Arg-NH2

12

98.24%

C₇₁H₁₂₆N₂₆O₁₂

1535.93

Synthetic

Powder

Innate defense regulator 1018 (IDR-1018) is a synthetic 12-amino acid derivative of bactenecin. IDR-1018 is a broad-spectrum antibiofilm peptide that acts by binding to the nucleotide (p)ppGpp. IDR-1018 (or just 1018) is a small cationic synthetic peptide (VRLIVAVRIWRR-NH2) that has been developed based on bactenecin, a peptide antibiotic isolated from bovine neutrophil granules.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Andresen, L., Tenson, T. & Hauryliuk, V. Cationic bactericidal peptide 1018 does not specifically target the stringent response alarmone (p)ppGpp. Sci Rep 6, 36549 (2016). https://doi.org/10.1038/srep36549

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.