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  • IA9 peptide

IA9 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319778

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* Buy 1 get 1 free (?) What is TFA?

Special Price 101.70 USD

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Product Information

  • Product Name
    IA9 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-IFLIKILAA-OH
  • Sequence
    H-Ile-Phe-Leu-Ile-Lys-Ile-Leu-Ala-Ala-OH
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.7%
  • Molecular Formula
    C51H88N10O10
  • Molecular Weight
    1001.3
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The IA9 peptide is a rationally designed 9-mer sequence (IFLIKILAA) derived from human TREM-2182–190, developed using the signaling chain homooligomerization (SCHOOL) model of cell signaling. This peptide employs a ligand-independent mechanism to inhibit TREM-2 by blocking its interaction with the signaling partner DAP-12 in the cell membrane. IA9 can be delivered either as a free peptide or incorporated into lipopeptide complexes (LPC) for targeted intracellular delivery to macrophages. In experimental collagen-induced arthritis (CIA), IA9 significantly suppresses joint inflammation and damage, reduces proinflammatory cytokine release, and decreases synovial tissue expression of inflammatory markers, demonstrating its potential as a modulator of TREM-2 signaling in inflammatory conditions.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Sigalov AB. Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis. Int J Mol Sci. 2022 Aug 9;23(16):8857. doi: 10.3390/ijms23168857. PMID: 36012120; PMCID: PMC9408405.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"