Hymenochirin-1Pb peptide

Hymenochirin-1Pb peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-LKLSPETKDTLKKVLKGAIKGAIAIASLA-NH2

H-Leu-Lys-Leu-Ser-Pro-Glu-Thr-Lys-Asp-Thr-Leu-Lys-Lys-Val-Leu-Lys-Gly-Ala-Ile-Lys-Gly-Ala-Ile-Ala-Ile-Ala-Ser-Leu-Ala-NH2

29

95.15%

C₁₃₆H₂₄₆N₃₆O₃₇

2977.61

Synthetic

Powder

Hymenochirin-1Pb is a host-defense peptide isolated from the skin secretions of Merlin's clawed frog (Pseudhymenochirus merlini, Africa).
Hymenochirin-1Pb is structurally similar to hymenochirin-1B from Hymenochirus boettgeri and belongs to the hymenochirin-1P family.
Hymenochirin-1Pb is one of the 13 host-defense peptides identified in the skin secretions of P. merlini, which have antimicrobial activity against bacteria such as Staphylococcus aureus (MIC 5 uM) and Escherichia coli (MIC > 40 uM). The peptides from P. merlini, including Hymenochirin-1Pb, have been characterized for their structural and biological properties, and their potential as antimicrobial agents is being explored.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Conlon JM, Prajeep M, Mechkarska M, et al. Characterization of the host-defense peptides from skin secretions of Merlin's clawed frog Pseudhymenochirus merlini: insights into phylogenetic relationships among the Pipidae. Comp Biochem Physiol Part D Genomics Proteomics. 2013;8(4):352-7.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.