Human TRIP12 Recombinant protein (GST tag)

Cat.#: 513910

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Product Information

  • Product Name
    Human TRIP12 Recombinant protein (GST tag)
  • Documents
  • Description
    E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {PubMed:18627766, PubMed:19028681, PubMed:20208519, PubMed:20829358, PubMed:22884692}.
  • Protein name
    E3 ubiquitin-protein ligase TRIP12
  • Protein short names
    KIAA0045; ULF
  • Uniprot ID
    Q14669
  • Gene Name
    TRIP12; KIAA0045; ULF
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    1643-1992 aa encoded by NM_001348315 was inserted into PGEX-4T vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human TRIP12 SDS-PAGE

    Recombinant human TRIP12 SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"