|Human PD-L1 inhibitor Ar5Y_4|
|Three letter code||H-Gly-Asn-Trp-Asp-Tyr-Asn-Ser-Gln-Arg-Ala-Gln-Leu-Tyr-Asn-Gln-OH|
|Peptide Purity (%)||98.62|
|Additional Information||Blocking the interaction of human programmed death 1 (hPD-1) and its ligand hPD-L1 has been a promising immunotherapy in cancer treatment. Human PD-L1 inhibitor (Ar5Y_4, GNWDYNSQRAQLYNQ) showed a KD value of 1.38 ± 0.39 μM, comparable to the binding affinity of the cognate hPD-L1. A Surface Plasmon Resonance (SPR) competitive binding assay result indicated that Ar5Y_4 could inhibit the interaction of hPD-1/hPD-L1. Moreover, Ar5Y_4 could restore the function of Jurkat T cells which had been suppressed by stimulated HCT116 cells. Human PD-L1 inhibitor provides promising biologic candidates for cancer immunotherapy or diagnostics.|
|Storage Guidelines||Ideally Human PD-L1 inhibitor Ar5Y_4 should be stored in a freezer at or below -9C. Human PD-L1 inhibitor Ar5Y_4 should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides|
|Terms||Please do not use the peptide for human consumption. NovoPro will immediately deny any order that we feel will be used outside of the scope of its intended purpose.|
Li Q, Quan L, Lyu J, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016;7(40):64967-64976
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