NovoPro
Cart 2
  • Human PD-L1 inhibitor Ar5Y_4

Human PD-L1 inhibitor Ar5Y_4

Cat.#: 318735

Size:

Special Price 145.6 USD

Availability: 1-2 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human PD-L1 inhibitor Ar5Y_4
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    GNWDYNSQRAQLYNQ
  • Three letter code
    H-Gly-Asn-Trp-Asp-Tyr-Asn-Ser-Gln-Arg-Ala-Gln-Leu-Tyr-Asn-Gln-OH
  • Length (aa)
    15
  • Peptide Purity (HPLC)
    98.62
  • Molecular Formula
    C80H113N25O27
  • Molecular Weight
    1856.89
  • Source
    Synthetic
  • Additional Information
    Blocking the interaction of human programmed death 1 (hPD-1) and its ligand hPD-L1 has been a promising immunotherapy in cancer treatment. Human PD-L1 inhibitor (Ar5Y_4, GNWDYNSQRAQLYNQ) showed a KD value of 1.38 ± 0.39 μM, comparable to the binding affinity of the cognate hPD-L1. A Surface Plasmon Resonance (SPR) competitive binding assay result indicated that Ar5Y_4 could inhibit the interaction of hPD-1/hPD-L1. Moreover, Ar5Y_4 could restore the function of Jurkat T cells which had been suppressed by stimulated HCT116 cells. Human PD-L1 inhibitor provides promising biologic candidates for cancer immunotherapy or diagnostics.
  • Storage Guidelines
    Ideally Human PD-L1 inhibitor Ar5Y_4 should be stored in a freezer at or below -9C. Human PD-L1 inhibitor Ar5Y_4 should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Li Q, Quan L, Lyu J, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016;7(40):64967-64976

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"