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catalog peptide: Human PD-L1 inhibitor Ar5Y_4

Human PD-L1 inhibitor Ar5Y_4

Cat.#: 318735

Special Price 145.6 USD

Availability: 1-2 weeks

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Description
Human PD-L1 inhibitor Ar5Y_4
Quantity/Unit 1 Vial
Sequence GNWDYNSQRAQLYNQ
Three letter code H-Gly-Asn-Trp-Asp-Tyr-Asn-Ser-Gln-Arg-Ala-Gln-Leu-Tyr-Asn-Gln-OH
Length 15
Peptide Purity (%) 98.62
Molecular Formula C80H113N25O27
Molecular Weight 1856.89
Source Synthetic
Additional Information Blocking the interaction of human programmed death 1 (hPD-1) and its ligand hPD-L1 has been a promising immunotherapy in cancer treatment. Human PD-L1 inhibitor (Ar5Y_4, GNWDYNSQRAQLYNQ) showed a KD value of 1.38 ± 0.39 μM, comparable to the binding affinity of the cognate hPD-L1. A Surface Plasmon Resonance (SPR) competitive binding assay result indicated that Ar5Y_4 could inhibit the interaction of hPD-1/hPD-L1. Moreover, Ar5Y_4 could restore the function of Jurkat T cells which had been suppressed by stimulated HCT116 cells. Human PD-L1 inhibitor provides promising biologic candidates for cancer immunotherapy or diagnostics.
Storage Guidelines Ideally Human PD-L1 inhibitor Ar5Y_4 should be stored in a freezer at or below -9C. Human PD-L1 inhibitor Ar5Y_4 should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
Terms Please do not use the peptide for human consumption. NovoPro will immediately deny any order that we feel will be used outside of the scope of its intended purpose.
References

Li Q, Quan L, Lyu J, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016;7(40):64967-64976

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