Human P62;SQSTM1 Recombinant protein (GST tag)

Human P62;SQSTM1 Recombinant protein (GST tag)

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• Material Safety Data Sheets (MSDS)

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. {, PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:15340068, PubMed:15802564, PubMed:15911346, PubMed:15953362, PubMed:16079148, PubMed:16286508, PubMed:19931284, PubMed:20168092, PubMed:24128730}.

Sequestosome-1

ORCA; OSIL

Q13501

SQSTM1; ORCA; OSIL

E. coli

A DNA sequence encoding the human SQSTM1 (NP_003891.1) 1-440 aa was fused with the N-terminal GST tag

Human

Not tested.