Human DNM1L,DLP1 Recombinant protein (His tag)

Cat.#: 507314

Size:

Special Price 294.7 USD

Availability: 2-3 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human DNM1L,DLP1 Recombinant protein (His tag)
  • Documents
  • Description
    Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.; Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.
  • Protein name
    Dynamin-1-like protein
  • Protein short names
    DLP1; DRP1
  • Uniprot ID
    O00429
  • Gene Name
    DNM1L; DLP1; DRP1
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human DNM1L (NP_036192.2) 69-142 aa was fused with the polyhistidine tag
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human DNM1L,DLP1 SDS-PAGE

    Recombinant human DNM1L,DLP1 SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"