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Product Name
Recombinant HR78 protein (His tag)
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Description
Recombinant Nuclear hormone receptor HR78 (dHR78) fragment (residues 361-601) from Drosophila melanogaster, designed for structural and biochemical studies. This 241-amino acid fragment represents a stable, soluble region of the receptor, ideal for investigating its role in gene regulation and molting processes.
Nuclear hormone receptor HR78 (dHR78) is a key transcriptional regulator in Drosophila melanogaster that binds to direct repeats of the sequence 5'-AGGTCA-3'. It functions as an inhibitor of the ecdysone response and plays an essential role in regulating molting of the tracheal cuticle during larval development. The protein localizes to the nucleus, consistent with its function as a nuclear receptor involved in gene expression regulation. This fragment provides a valuable tool for studying the structural basis of HR78's regulatory functions without interference from full-length protein instability.
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Protein name
Nuclear hormone receptor HR78
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Uniprot ID
Q24142
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Gene Name
Hr78; Hr78D; NR2D1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 361-601 aa (Q24142) were fused with 6His tag.
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Protein Species
Drosophila melanogaster
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Molecular weight
Predictes a molecular mass of 28.88 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 29 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"