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Product Name
HMCN1 antibody
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Description
HMCN1 Rabbit Polyclonal antibody. Positive IHC detected in human colon tissue. Positive WB detected in mouse skin tissue. Observed molecular weight by Western-blot: 60 kDa
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Tested applications
ELISA, IHC, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ARMD1 antibody; FBLN6 antibody; FIBL 6 antibody; FIBL6 antibody; Fibulin 6 antibody; hemicentin 1 antibody; HMCN1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_031935). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human colon using Catalog No:111474(HMCN1 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human colon using Catalog No:111474(HMCN1 antibody) at dilution of 1:50 (under 40x lens)
mouse skin tissue were subjected to SDS PAGE followed by western blot with Catalog No:111474(HMCN1 Antibody) at dilution of 1:1000
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Background
Hemicentin-1 (HMCN1), also known as fibulin-6 (FIBL-6), is an extracellular protein of the immunoglobulin superfamily. HMCN1 consists of a von Willebrand A domain, tandem immunoglobulin modules, tandem EGF modules, and a fibulin carboxy-terminal module (PMID: 24912920). Mutations of HMCN1 gene may be associated with age-related macular degeneration. Three alternative transcripts encoding different HMCN1 isoforms have been described. This antibody raised against a synthesized peptide corresponding to 960-916 amino acids of human HMCN1 can recognize all three isoforms of HMCN1.
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