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Product Name
Recombinant HHATL protein (His tag)
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Description
This recombinant protein is a fragment (residues 311-428) of the human HHATL protein, also known as Protein-cysteine N-palmitoyltransferase HHAT-like protein. It represents a stable and soluble unit ideal for investigating the regulatory mechanisms of Hedgehog signaling and protein palmitoylation.
The full-length HHATL protein, encoded by the HHATL gene, functions as a negative regulator of N-terminal palmitoylation of Sonic Hedgehog (SHH) by HHAT/SKN. This regulatory role is critical in modulating Hedgehog signaling pathways, which are essential for cell differentiation and development. The protein is localized to the endoplasmic reticulum membrane as a multi-pass membrane protein, indicating its involvement in intracellular processing and modification of signaling molecules.
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Protein name
Protein-cysteine N-palmitoyltransferase HHAT-like protein
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Uniprot ID
Q9HCP6
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Gene Name
HHATL; C3orf3; GUP1; KIAA1173
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 311-428 aa (Q9HCP6) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 15.05 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"