Halictine 2 peptide

Halictine 2 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

GKWMSLLKHILK-NH2

H-Gly-Lys-Trp-Met-Ser-Leu-Leu-Lys-His-Ile-Leu-Lys-NH2

12

98.65%

C₆₉H₁₁₇N₁₉O₁₃S

1452.85

Synthetic

Powder

Highly active against B. subtilis, S. aureus, E. coli (MIC 0.8-7.7 uM) and moderately active against P. aeruginosa (MIC ~45 uM). Also active against C. albicans (MIC 6-7 uM) as well as cancer cells such as Hela S3, CRC SW480, and CCRF-CEMT IC50=12-35 uM (Slaninova J et al. 2012 Peptides 33:18-26). Secondary structures were determined by both CD and NMR. Numerous variants were generated to understand the sequence-activity relationships. Provided by Vaclav Cerovsky on Jannary 27, 2012. Halictine 2 has Antibacterial activity. The source of Halictine 2 is venom, the eusocial bee, Halictus sexcinctus.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Monincová L, Budesínský M, Slaninová J, et al. Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs. Amino Acids. 2010;39(3):763-75.
• Melicherčík P, Nešuta O, Čeřovský V. Antimicrobial Peptides for Topical Treatment of Osteomyelitis and Implant-Related Infections: Study in the Spongy Bone. Pharmaceuticals (Basel). 2018 Feb 16;11(1):20.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.