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Product Name
Recombinant H4 protein (His tag)
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Description
Recombinant Human Histone H4 (residues 2-103) is a high-quality protein fragment engineered for stability and solubility, ideal for structural biology and biochemical studies. This product captures the essential core domain of Histone H4, enabling researchers to investigate its critical role in chromatin organization and DNA regulation with enhanced experimental utility.
Histone H4 is a core component of the nucleosome, the fundamental unit of chromatin. It plays a central role in wrapping and compacting DNA into chromatin, thereby regulating DNA accessibility for key cellular processes such as transcription, DNA repair, replication, and chromosomal stability. The protein's function is modulated through a complex set of post-translational modifications, known as the histone code, and nucleosome remodeling mechanisms. Histone H4 is localized to the nucleus and chromosomes, where it contributes to epigenetic regulation and genome integrity.
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Protein name
Histone H4
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Uniprot ID
P62805
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Gene Name
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4/A; H4FA; HIST1H4A;; H4/I; H4FI; HIST1H4B;; H4/G; H4FG; HIST1H4C;; H4/B; H4FB; HIST1H4D;; H4/J; H4FJ; HIST1H4E;; H4/C; H4FC; HIST1H4F;; H4/H; H4FH; HIST1H4H;; H4/M; H4FM; HIST1H4I;; H4/E; H4FE; HIST1H4J;; H4/D; H4FD; HIST1H4K;; H4/K; H4FK; HIST1H4L;; H4/N; H4F2; H4FN; HIST2H4; HIST2H4A;; H4/O; H4FO; HIST2H4B;; H4-16; HIST4H4
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 2-103 aa (P62805) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 12.89 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 13 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"