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Product Name
Recombinant H15 protein (His tag)
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Description
Recombinant Human Histone H1.5 Fragment (39-113) is a high-purity protein designed for chromatin and gene regulation studies. This fragment contains the complete H15 functional domain, offering a precise tool to investigate the specific mechanisms of histone H1 in DNA binding, nucleosome spacing, and chromatin remodeling.
Histone H1.5 is a linker histone that binds to DNA between nucleosomes, playing a critical role in chromatin fiber condensation and higher-order chromatin structure formation. It functions as a key regulator of gene transcription by influencing chromatin remodeling, nucleosome spacing, and DNA methylation. The protein is primarily localized in the nucleus and is associated with chromosomes, with studies indicating its presence in both heterochromatin and actively transcribed chromatin regions, highlighting its dynamic involvement in genomic organization and transcriptional control.
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Protein name
Histone H1.5
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Uniprot ID
P16401
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Gene Name
H1-5; H1F5; HIST1H1B
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 39-113 aa (P16401) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 9.32 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 9 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"