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  • TFLLR-NH2 peptide

TFLLR-NH2 peptide

Not For Human Use, Lab Use Only.

Cat.#: 310538

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* Buy 1 get 1 free (?) What is TFA?

Special Price 75.90 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    TFLLR-NH2 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    TFLLR
  • Sequence
    H-Thr-Phe-Leu-Leu-Arg-NH2
  • Length (aa)
    5
  • Peptide Purity (HPLC)
    96.7%
  • Molecular Formula
    C31H53N9O6
  • Molecular Weight
    647.82 net
  • Source
    Synthetic
  • Form
    Powder
  • Description
    TFLLR-NH2 is a peptide derived from the protease activated receptor 1 (PAR1) that acts as a PAR1 selective agonist, with an EC50 of 1.9 μM. TFLLR-NH2 is widely used to activate platelets and has also been shown to elicit scratching in mice. Platelet activation of SW620 colon cancer cells with TFLLR-NH2 triggers TGF-β secretion, which induces epithelial-mesenchymal transition (EMT) through the downregulation of miR-200b expression. Activated platelets have a chemotactic effect on colon cancer cells mediated by the upregulation of CXCR4 on the cell surface.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • M.Saifeddine et al., Br. J. Pharmacol., 132, 556 (2001)
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight

Peptide Property

  • Analysed Sequence:A
  • Chemical Formula:A
  • Sequence length:A
  • Extinction coefficient:A M-1cm-1
  • GRAVY:A
  • Mw average:A
  • Theoretical pI:A
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"