GsMTx4 peptide
Not For Human Use, Lab Use Only.
Cat.#: 319770
Special Price 689.00 USD
Availability:
4 weeks
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Product Name
GsMTx4 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF-NH2
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Sequence
H-Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2
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Length (aa)
34
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Peptide Purity (HPLC)
95.79%
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Molecular Formula
C185H273N49O45S6
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Molecular Weight
4095.82
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CAS No.
1209500-46-8
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PubChem CID
90488987
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Source
Synthetic
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Form
Powder
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Description
GsMTx4 is a 34-amino acid peptide toxin isolated from the venom of the Chilean rose tarantula spider Grammostola spatulata. It belongs to the inhibitor cystine knot (ICK) family, characterized by three disulfide bonds forming a stable structural motif. GsMTx4 specifically inhibits stretch-activated cation channels, though its mechanism involves interaction with the lipid bilayer surrounding the channels rather than direct binding to channel proteins.
Structural analysis reveals that GsMTx4 folds into two interconnected rings, a conformation stabilized by its cysteine knots. This peptide has been shown to block mechanosensitive currents in various cell types, including astrocytes and cardiomyocytes, suggesting a broad modulatory role in mechanotransduction pathways. Its unique selectivity makes it a valuable tool for studying mechanosensitive ion channels and their physiological functions.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Park SP, Kim BM, Koo JY, Cho H, Lee CH, Kim M, Na HS, Oh U. A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain. 2008 Jul;137(1):208-217. doi: 10.1016/j.pain.2008.02.013. Epub 2008 Mar 24. PMID: 18359568.
- Gnanasambandam R, Ghatak C, Yasmann A, Nishizawa K, Sachs F, Ladokhin AS, Sukharev SI, Suchyna TM. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J. 2017 Jan 10;112(1):31-45. doi: 10.1016/j.bpj.2016.11.013. PMID: 28076814; PMCID: PMC5231890.
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About TFA salt
Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.
Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
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• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"