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Product Name
Recombinant GRWD1 protein (His tag)
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Description
Recombinant Glutamate-rich WD repeat-containing protein 1 (GRWD1) fragment (amino acids 34-446) is a high-purity, stable protein designed for chromatin dynamics and DNA replication studies. This 413-amino acid fragment, derived from human GRWD1, retains key functional properties and is ideal for structural, biochemical, and interaction assays.
Glutamate-rich WD repeat-containing protein 1 (GRWD1) is a histone-binding protein that plays a critical role in chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, potentially by enhancing chromatin openness. It localizes to the nucleus and nucleolus, associates with chromosomes during interphase, and detaches from chromatin during mitosis before rebinding at telophase during pre-replication complex formation. This protein is essential for regulating DNA replication initiation and maintaining genomic stability.
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Protein name
Glutamate-rich WD repeat-containing protein 1
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Uniprot ID
Q9BQ67
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Gene Name
GRWD1; GRWD; KIAA1942; WDR28
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 34-446 aa (Q9BQ67) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 47.54 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 52 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"