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Product Name
Recombinant GRPE protein (His tag)
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Description
The GrpE protein homolog, mitochondrial (residues 1-237) from Caenorhabditis elegans is a high-purity recombinant fragment engineered for stability and solubility. This product supports research into mitochondrial protein import mechanisms, specifically the ATP-dependent translocation processes mediated by the PAM complex, making it ideal for structural and biochemical studies.
The full-length GrpE protein homolog is an essential component of the PAM complex, which facilitates the ATP-dependent translocation of transit peptide-containing proteins from the inner mitochondrial membrane into the matrix. It functions by regulating the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins, ensuring efficient protein import and mitochondrial function. This protein is localized within the mitochondrial matrix, underscoring its critical role in maintaining mitochondrial homeostasis and cellular energy production.
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Protein name
GrpE protein homolog, mitochondrial
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Uniprot ID
Q18421
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-237 aa (Q18421) were fused with 6His tag.
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Protein Species
Caenorhabditis elegans
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Molecular weight
Predictes a molecular mass of 28.10 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 30 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"