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  • GPTIEEVD peptide

GPTIEEVD peptide

Not For Human Use, Lab Use Only.

Cat.#: 319190

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Optional Service: TFA RemovalWhat's this?

Special Price 94.2 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    GPTIEEVD peptide
  • Documents
  • Sequence Shortening
    H-GPTIEEVD-OH
  • Sequence
    H-Gly-Pro-Thr-Ile-Glu-Glu-Val-Asp-OH
  • Length (aa)
    8
  • Peptide Purity (HPLC)
    95.79%
  • Molecular Formula
    C36H58N8O16
  • Molecular Weight
    858.88
  • Source
    Synthetic
  • Form
    Powder
  • Description
    The TPR domain of CHIP ubiquitin ligase interacts not only with the C-terminal GPTIEEVD motif of Hsp70/Hsc70 but also with the α-helical lid subdomain of the chaperone. GPTIEEVD peptide strongly perturbed the <sup>15</sup>N-CHIP-TPR spectrum in a manner indicating slow exchange binding.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Zhang H, Amick J, Chakravarti R, Santarriaga S, Schlanger S, McGlone C, Dare M, Nix JC, Scaglione KM, Stuehr DJ, Misra S, Page RC. A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins. Structure. 2015 Mar 3;23(3):472-482.
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"