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  • Gp100 (25-33), mouse peptide

Gp100 (25-33), mouse peptide

Not For Human Use, Lab Use Only.

Cat.#: 319817

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* Buy 1 get 1 free (?) What is TFA?

Special Price 101.70 USD

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Product Information

  • Product Name
    Gp100 (25-33), mouse peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-EGSRNQDWL-OH
  • Sequence
    H-Glu-Gly-Ser-Arg-Asn-Gln-Asp-Trp-Leu-OH
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.71%
  • Molecular Formula
    C46H69N15O17
  • Molecular Weight
    1104.12
  • CAS No.
    212370-36-0
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The Gp100 (25-33), mouse peptide (EGSRNQDWL) is a melanoma-associated antigen derived from the murine gp100 protein. This peptide is presented by the H-2Db major histocompatibility complex (MHC) class I molecules on antigen-presenting cells and tumor cell lines. It serves as a target for T-cell receptor recognition, playing a role in immune responses against melanoma. The peptide shares homology with its human counterpart (KVPRNQDWL), though differences in amino acid sequences result in varying affinities for MHC-I binding and T-cell activation.

    Studies have utilized the Gp100 (25-33) peptide to investigate TCR-MHC interactions, particularly in models involving transgenic T cells or hybridomas. Its presentation on dendritic cells and tumor lines enables the study of antigen processing and immune recognition mechanisms. The peptide's structural features and MHC-I binding properties make it a useful tool for probing low- and high-affinity peptide-TCR interactions in experimental systems.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Cafri G, Sharbi-Yunger A, Tzehoval E, Eisenbach L. Production of LacZ inducible T cell hybridoma specific for human and mouse gp100₂₅₋₃₃ peptides. PLoS One. 2013;8(2):e55583. doi: 10.1371/journal.pone.0055583. Epub 2013 Feb 1. PMID: 23383339; PMCID: PMC3562179.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"