GLP-2(1-33)(Chiken) / Glucagon-like peptide 2 (Gallus gallus)
Not For Human Use, Lab Use Only.
Cat.#: 319891
Special Price 303.10 USD
Availability:
4 weeks
-
Product Name
GLP-2(1-33)(Chiken) / Glucagon-like peptide 2 (Gallus gallus)
-
Documents
Batch to batch variation of the purity
-
Sequence Shortening
HADGTFTSDINKILDDMAAKEFLKWLINTKVTQ
-
Sequence
His-Ala-Asp-Gly-Thr-Phe-Thr-Ser-Asp-Ile-Asn-Lys-Ile-Leu-Asp-Asp-Met-Ala-Ala-Lys-Glu-Phe-Leu-Lys-Trp-Leu-Ile-Asn-Thr-Lys-Val-Thr-Gln
-
Length (aa)
33
-
Peptide Purity (HPLC)
95.9%
-
Molecular Formula
C169H267N43O52S
-
Molecular Weight
3765.311
-
Source
Synthetic
-
Form
Powder
-
Description
GLP-2(1-33) (chicken) is a 33-amino-acid peptide derived from the proglucagon gene, which in chickens gives rise to multiple bioactive peptides including glucagon, oxyntomodulin, GLP-1, and GLP-2 through tissue-specific post-translational processing. In the brain and intestine, proglucagon is cleaved to liberate GLP-2 alongside other glucagon-like peptides, and the mature chicken GLP-2 sequence shares only about 51–55% amino acid identity with its mammalian counterparts, indicating considerable structural divergence across vertebrates.
The chicken GLP-2 receptor is expressed in the brain and gastrointestinal tract, and its activation by the homologous chicken peptide occurs with high specificity, as structurally related peptides such as GLP-1 and glucagon do not potently activate it. In the chicken small intestine, GLP-2 colocalizes with GLP-1 within the same secretory granules of L cells, and central administration of the chicken peptide has been shown to suppress food intake, suggesting a role for GLP-2 in the neuroendocrine regulation of energy homeostasis in this species.
-
Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
-
References
- Honda K. Glucagon-related peptides and the regulation of food intake in chickens. Anim Sci J. 2016 Sep;87(9):1090-8. doi: 10.1111/asj.12619. Epub 2016 May 6. PMID: 27150835; PMCID: PMC5084811.
-
About TFA salt
Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.
Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.
-
Molar Concentration Calculator
-
Dilution Calculator
-
Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"