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  • Gersizangitide peptide

Gersizangitide peptide

Not For Human Use, Lab Use Only.

Cat.#: 319833

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* Buy 1 get 1 free (?) What is TFA?

Special Price 183.50 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Gersizangitide peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-LRRFSTAPFAFIDINDVINF-NH2
  • Sequence
    H-Leu-Arg-Arg-Phe-Ser-Thr-Ala-Pro-Phe-Ala-Phe-Ile-Asp-Ile-Asn-Asp-Val-Ile-Asn-Phe-NH2
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    95.33%
  • Molecular Formula
    C111H167N29O28
  • Molecular Weight
    2355.68
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Gersizangitide (AXT107) is a 20-amino acid peptide derived from collagen IV, functioning as an angiogenic inhibitor. It exhibits dual activity by inhibiting VEGF-A and VEGF-C while activating the Tie2 receptor. This peptide effectively blocks VEGF receptor signaling, thereby suppressing vascular leakage in ischemic retinopathy and choroidal neovascularization models. Gersizangitide demonstrates potential in inhibiting neovascularization, vascular leakage, and inflammation, offering a promising approach for treating neovascular retinal diseases with a potential dosing interval of once per year.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Mirando AC, Shen J, Silva RLE, Chu Z, Sass NC, Lorenc VE, Green JJ, Campochiaro PA, Popel AS, Pandey NB. A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling. JCI Insight. 2019 Feb 21;4(4):e122043. doi: 10.1172/jci.insight.122043. PMID: 30668550; PMCID: PMC6478425.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"