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Product Name
Recombinant FOXI1 protein (His tag)
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Description
Recombinant Human FOXI1 Protein Fragment (122-212) is a highly stable and soluble unit derived from the Forkhead box protein I1, designed for structural and biochemical studies. This fragment retains key features suitable for investigating transcriptional regulation mechanisms in hearing, balance, and kidney function research.
The full-length Forkhead box protein I1 (FOXI1) is a transcriptional activator essential for normal hearing, balance, and kidney function. It regulates the expression of critical genes such as SLC26A4/PDS, JAG1, and COCH in inner ear epithelial cells, contributing to endolymphatic system development. In renal tubules, FOXI1 drives the expression of SLC4A1/AE1, SLC4A9/AE4, and ATP6V1B1, facilitating intercalated cell differentiation. As a nuclear protein, it operates within the nucleus to mediate these vital physiological processes, underscoring its importance in developmental and cellular biology.
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Protein name
Forkhead box protein I1
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Uniprot ID
Q12951
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Gene Name
FOXI1; FKHL10; FREAC6
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 122-212 aa (Q12951) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 12.16 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 12 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"