FLP-20 neuropeptides：AMMRFa, AVFRMa, SVFRLa

FLP-20 neuropeptides：AMMRFa, AVFRMa, SVFRLa

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

AMMRF-NH2, AVFRM-NH2, SVFRL-NH2

5

95.8%

C₂₈H₄₇N₉O₅S₂

653.86

Synthetic

Powder

All three peptides encoded by the flp-20 gene (AMMRFa, AVFRMa, SVFRLa) were able to activate FRPR-3 receptor, the FMRFamide-like peptide GPCR FRPR-3, with EC50 values in the low nanomolar range. AMMRFa refers to AMMRF-NH2(C₂₈H₄₇N₉O₅S₂, MW: 653.86); AVFRMa = AVFRM-NH2(C₂₈H₄₇N₉O₅S, MW: 621.79); SVFRLa = SVFRL-NH2(C₂₉H₄₉N₉O₆, MW: 619.75). These FLP-20 peptides function as an afferent arousal signal that conveys mechanosensory information to central neurons that modulate arousal and other behavioral states.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Chew et al., An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans, Neuron (2018), https://doi.org/10.1016/j.neuron.2018.08.003

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.