FLP-20 neuropeptides：AMMRFa, AVFRMa, SVFRLa
AMMRF-NH2, AVFRM-NH2, SVFRL-NH2
Peptide Purity (HPLC)
All three peptides encoded by the flp-20 gene (AMMRFa, AVFRMa, SVFRLa) were able to activate FRPR-3 receptor, the FMRFamide-like peptide GPCR FRPR-3, with EC50 values in the low nanomolar range. AMMRFa refers to AMMRF-NH2(C28H47N9O5S2, MW: 653.86); AVFRMa = AVFRM-NH2(C28H47N9O5S, MW: 621.79); SVFRLa = SVFRL-NH2(C29H49N9O6, MW: 619.75). These FLP-20 peptides function as an afferent arousal signal that conveys mechanosensory information to central neurons that modulate arousal and other behavioral states.
Ideally FLP-20 neuropeptides：AMMRFa, AVFRMa, SVFRLa should be stored in a freezer at or below -9C. FLP-20 neuropeptides：AMMRFa, AVFRMa, SVFRLa should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
- Chew et al., An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans, Neuron (2018), https://doi.org/10.1016/j.neuron.2018.08.003
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